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Background: Epidemiological studies have suggested that vitamin D deficiency is associated with the development of type 2 diabetes (T2DM) and is related to diabetes complications. This study was undertaken to determine the relationship between diabetes complications and cardiovascular risk factors with vitamin D 3 and its metabolites: 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), 25-hydroxyvitamin D 3 (25(OH)D 3 ), 24,25-dihydroxyvitamin D 3 (24,25(OH) 2 D 3 ); and 25-hydroxy-3epi-vitamin D 3 (3epi25(OH)D 3 ). Methods: 750 Qatari subjects, 460 (61.3%) with and 290 (38.7%) without T2DM, who were not taking vitamin D 3 supplements, participated in this cross-sectional, observational study. Plasma concentrations of vitamin D 3 and its metabolites were measured by liquid chromatography tandem mass spectrometry analysis. Results: T2DM subjects had lower concentrations of all vitamin D 3 metabolites ( p |
