A clinical trial with combined transcranial direct current stimulation and alcohol approach bias retraining
| Autor: | den Uyl, T.E., Gladwin, T.E., Rinck, M., Lindenmeyer, J., Wiers, R.W. |
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| Přispěvatelé: | Ontwikkelingspsychologie (Psychologie, FMG) |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Addiction Biology, 22, 6, pp. 1632-1640 Addiction Biology, 22, 1632-1640 Addiction Biology, 22(6). Wiley-Blackwell |
| ISSN: | 1355-6215 |
| DOI: | 10.1111/adb.12463 |
| Popis: | Contains fulltext : 177700.pdf (Publisher’s version ) (Closed access) Two studies showed an improvement in clinical outcomes after alcohol approach bias retraining, a form of Cognitive Bias Modification (CBM). We investigated whether transcranial direct current stimulation (tDCS) could enhance effects of CBM. TDCS is a neuromodulation technique that can increase neuroplasticity and has previously been found to reduce craving. One hundred alcohol-dependent inpatients (91 used for analysis) were randomized into three experimental groups in a double-blind parallel design. The experimental group received four sessions of CBM while receiving 2 mA of anodal tDCS over the dorsolateral prefrontal cortex (DLPFC). There were two control groups: One received sham stimulation during training and one received active stimulation at a different moment. Treatment outcomes were abstinence duration (primary) and relapse after 3 and 12 months, craving and approach bias (secondary). Craving and approach bias scores decreased over time; there were no significant interactions with experimental condition. There was no effect on abstinence duration after three months (X2(2) = 3.53, p = 0.77). However, a logistic regression on relapse rates after one year (standard outcome in the clinic, but not-preregistered) showed a trend when relevant predictors were included; relapse was lower in the condition receiving active stimulation during CBM only when comparing to sham stimulation (B = 1.52, S.E. = .836, p = .07, without predictors: p = .19). No strong evidence for a specific enhancement effect of tDCS on CBM was found. However, in a post-hoc analysis, tDCS combined with CBM showed a promising trend on treatment outcome. Important limitations are discussed, and replication is necessary to find more reliable effects. 9 p. |
| Databáze: | OpenAIRE |
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