Effect of the treatment with growth hormone in idiopathic short stature with moderate GH deficiency or partial GH insensitivity
| Autor: | Cardoso, Daniela Felix |
|---|---|
| Přispěvatelé: | Oliveira, Manuel Hermínio de Aguiar |
| Jazyk: | portugalština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFS Universidade Federal de Sergipe (UFS) instacron:UFS |
| Popis: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Idiopathic Short Stature is a heterogeneous set of conditions without obvious hormonal changes or defined etiologies. It may include the partial insensitivity to GH (PGHI) and the moderate GH deficiency (MGHD), both of them with low concentrations of growth factor like insulin type I (IGF-I) and hyper or sub-answer of GH on tests of stimulation, respectively. The objective of this study is to assess the response to treatment with GH in PGHI and MGHD, comparing them twith the results obtained in a group with severe GH deficiency (SGHD). It was studied in PGHI (GH peak ≥18 ng/ml) 20 individuals (14 boys), 12.07 (2.57-year-old); in MGHD (GH peak between 5 and 10 ng/ml) 12 (7 boys), 10.73 (1.79-year-old); and in SGHD (GH peak lower than 5 ng/ml) 19 (10 boys), 10.90-(3.51) yearold, treated with GH for one to ten years. The initial and present GH doses were, respectively, 43.33(10.00) and 49.61 (12.90) μg/kg/day in SGHD, 50.27 (11.76) and 57.27 (15.83) μg/kg/day in MGHD; and50.18 (6.99) and 55.66 (9.61) μg/kg/day in PGHI. The standard deviation score (SDS) of initial height of the SGHD group was lower than MGHD group (p< 0.01) and PGHI group (p |
| Databáze: | OpenAIRE |
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