Acute phase proteins but not activated microglial cells are present in parenchymal β A4 deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
| Autor: | Rozemuller, J. M., Bots, G. T.A.M., Roos, R. A.C., Eikelenboom, P. |
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| Přispěvatelé: | Pathology, Psychiatry |
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Zdroj: | Neuroscience Letters, 140(2), 137-140. Elsevier Ireland Ltd Rozemuller, J M, Bots, G T A M, Roos, R A C & Eikelenboom, P 1992, ' Acute phase proteins but not activated microglial cells are present in parenchymal β A4 deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type ', Neuroscience Letters, vol. 140, no. 2, pp. 137-140 . https://doi.org/10.1016/0304-3940(92)90087-N |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(92)90087-N |
| Popis: | With immunohistochemical staining methods on cryostat sections we investigated the brains of three patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type, one of the cerebral β A4 amyloid diseases. Immunostaining for β A4 protein revealed numerous non-fibrillar β A4 depositions (amorphous or diffuse plaques) in the brain parenchyma in addition to extensive vascular amyloid deposition. All amorphous plaques contain complement proteins and α1-antichymotrypsin but activated microglial cells expressing major histocompatibility (MHC) class II antigens HLA-DR and leucocyte adhesion molecules belonging to the lymphocyte-function-associated antigen (LFA)-1 family are virtually absent in cortical gray matter. Our findings are discussed from the view that a cascade of events including acute phase proteins and activated microglial cells are involved in classical amyloid plaque formation. |
| Databáze: | OpenAIRE |
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