Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
| Autor: | Liu, Yang, Sethi, Nilay S, Hinoue, Toshinori, Schneider, Barbara G, Cherniack, Andrew D, Sanchez-Vega, Francisco, Seoane, Jose A, Farshidfar, Farshad, Bowlby, Reanne, Islam, Mirazul, Kim, Jaegil, Chatila, Walid, Akbani, Rehan, Kanchi, Rupa S, Rabkin, Charles S, Willis, Joseph E, Wang, Kenneth K, McCall, Shannon J, Mishra, Lopa, Ojesina, Akinyemi I, Bullman, Susan, Pedamallu, Chandra Sekhar, Lazar, Alexander J, Sakai, Ryo, Cancer Genome Atlas Research Network, Thorsson, Vésteinn, Bass, Adam J, Laird, Peter W |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
tumor Cancer Research Oncology and Carcinogenesis Cancer Genome Atlas Research Network Adenocarcinoma Heterogeneous-Nuclear Ribonucleoproteins Proto-Oncogene Proteins p21(ras) genomic Rare Diseases Genetic Chromosomal Instability Genetics Humans cancer rectum Gene Regulatory Networks Oncology & Carcinogenesis Polymorphism Poly-ADP-Ribose Binding Proteins Gastrointestinal Neoplasms colorectal esophagus colon Human Genome Neurosciences RNA-Binding Proteins SOX9 Transcription Factor DNA Polymerase II Single Nucleotide Cell Biology DNA Methylation Aneuploidy Colo-Rectal Cancer DNA-Binding Proteins Oncology Mutation Female Microsatellite Instability methylation MutL Protein Homolog 1 Digestive Diseases epigenetic stomach Epigenesis |
| Zdroj: | Cancer cell, vol 33, iss 4 |
| Popis: | We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with epigenetic silencing of MLH1 in the context of CpG island methylator phenotype, plus tumors with elevated single-nucleotide variants associated with mutations in POLE. Tumors with chromosomal instability were diverse, with gastroesophageal adenocarcinomas harboring fragmented genomes associated with genomic doubling and distinct mutational signatures. We identified a group of tumors in the colon and rectum lacking hypermutation and aneuploidy termed genome stable and enriched in DNA hypermethylation and mutations in KRAS, SOX9, and PCBP1. Liu et al. analyze 921 gastrointestinal (GI) tract adenocarcinomas and find that hypermutated tumors are enriched for insertions/deletions, upper GI tumors with chromosomal instability harbor fragmented genomes, and a group of genome-stable colorectal tumors are enriched in mutations in SOX9 and PCBP1. |
| Databáze: | OpenAIRE |
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