Association between atherogenic index of plasma and left ventricular hypertrophy in patients with chronic heart failure with mid-range ejection fraction

Autor: Nikolov, Asparuh, Tzekova, Maria, Kostov, Konstantin, Kostadinovska, Ana, Blazheva, Svetla
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Medicina Fluminensis : Medicina Fluminensis
Volume 58
Issue 1
ISSN: 1848-820X
1847-6864
Popis: Aim: The aim of the present study was to investigate whether an association between lipid indices- atherogenic index of plasma (AIP), Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II) and triglyceride index (TGL-index) and the development of left ventricular hypertrophy exists in patients with heart failure with mid-range ejection fraction (HFmrEF). Material and methods: The study involved 56 patients with HFmrEF and normal lipid profile, median age 64 (47-84) and 22 healthy subjects, median age 58 (51-69). The patients were divided in two subgroups: subjects with left ventricular hypertrophy (n=32); (HFmrEF+LVH) and subjects without left ventricular hypertrophy (n=24); (HFmrEF-LVH). The lipid profile was measured by laboratory, while lipid indices were calculated, using the established formulas. Results: There was not statistically significant difference between the lipid indices in patients with heart failure with mid-range ejection fraction compared to healthy controls (p>0.05). HFmrEF+LVH patients showed statistically significantly higher values of atherogenic index of plasma than HFrEF-LVH patients: 0.16 (0.05/0.37) vs. 0.04 (0.01/0.11); (KW=5.80; p=0.02). TC/HDL, LDL/HDL and TG/HDL values were not significantly higher in HFmrHEF+LVH than HFmrEF-LVH patients: 4.8 (3.98/5.75) vs. 4.49 (3.58/5.63); 2.91 (2.1/4.0) vs. 2.9 (2.5/4.25) and 1.36 (1.11/2.08) vs. 1.13 (0.9/1.53), respectively (p>0.05). No significant gender differences between lipid indices were found. Atherogenic index of plasma showed correlation with LVH (r=0.45; p=0.01) and interventricular septum thickness (r=0.55; p=0.002). Conclusion: Our findings show an association between atherogenic index of plasma and LVH in patients with HFmrEF with normal lipid profile. Further studies are warranted to confirm whether determination of AIP may be used for monitoring development and progression of left ventricular hypertrophy in heart failure with mid-range ejection fraction.
Cilj: Cilj ove studije bio je istražiti postoji li povezanost između lipidnih indeksa - aterogeni indeks plazme (engl. atherogenic index of plasma; AIP), Castellijev indeks rizika I (engl. Castelli Risk Index I; CRI-I), Castellijev indeks rizika II (engl. Castelli Risk Index II; CRI-II) i trigliceridni indeks (engl. triglyceride index; TGL-index) i razvoj hipertrofije lijeve klijetke postoji u bolesnika sa zatajivanjem srca s umjereno smanjenom ejekcijskom frakcijom (HFmrEF). Materijali i metode: Ispitano je 56 bolesnika s HFmrEF s normalnim lipidnim profilom, prosječne dobi 64 (47 - 84) godine i 22 zdravih ispitanika prosječne dobi 58 (51 - 69). Pacijenti su podijeljeni u dvije podskupine: ispitanici s hipertrofijom lijeve klijetke (n = 32) (HFmrEF+LVH) i ispitanici bez hipertrofije lijeve klijetke (n = 24) (HFmrEF-LVH). Profil lipida mjeren je laboratorijski, dok su indeksi lipida izračunati pomoću ustaljenih formula. Rezultati: Nije bilo statistički značajne razlike između indeksa lipida u bolesnika sa srčanim zatajenjem s izbacivačkom frakcijom srednjeg opsega u usporedbi sa zdravim kontrolama (p > 0,05). Pacijenti s HFmrEF+LVH pokazali su statistički značajno veće vrijednosti aterogenog indeksa plazme od bolesnika s HFmrEF-LVH: 0,16 (0,05 / 0,37) naspram 0,04 (0,01 / 0,11) (KW = 5,80; p = 0,02). Vrijednosti TC/HDL, LDL/ HDL i TG/HDL nisu bile statistički značajno više u bolesnika s HFmrEF+LVH nego u skupini HFmrEF-LVH: 4,8 (3,98 / 5,75) naspram 4,59 (3,58 / 5,63), 2,91 (2,1 / 4.0) naspram 2,9 (2,5 / 4,25), odnosno 1,36 (1,11 / 2,08) naspram 1,13 (0,9 / 1,53) (p > 0,05). Nisu pronađene značajne razlike između indeksa lipida koje bi ovisile o spolu ispitanika. Aterogeni indeks plazme pokazao je korelaciju s LVH (r = 0,45; p = 0,01) i debljinom interventrikularnog septuma (r = 0,55; p = 0,002). Zaključak: Naši nalazi pokazuju povezanost između aterogenog indeksa plazme i LVH u bolesnika s HFrEF s normalnim lipidnim profilom. Daljnja ispitivanja opravdana su kako bi se potvrdilo može li se određivanje AIP koristiti za praćenje razvoja i napredovanja hipertrofije lijeve klijetke u zatajenju srca s izbacivačkom frakcijom srednjeg raspona.
Databáze: OpenAIRE
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