VEGF-R1 activation increases survival of purified retinal ganglion cells
| Autor: | Froger, Nicolas, Forster, Valérie, Ivkovic, Ivana, Pain, Dorothée, Brunel, Nadège, Fouquet, Stéphane, Sahel, José-Alain, Picaud, Serge |
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| Přispěvatelé: | Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Syndrome de Usher et autres atteintes rétino-cochléaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), BRUNEL, Nadège |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | luminex useurs meeting luminex useurs meeting, Oct 2012, Lisbonne, Portugal |
| Popis: | International audience; Retinal ganglion cell (RGC) damages are the ultimate and common process characterizing degenerative retinopathies, like glaucoma. In these diseases, no treatment is yet available to directly target RGC degeneration. Previously, we reported that a retinal conditioned medium was able to increase adult RGC survival in pure cultures 1. Our aim was to therefore identify RGC neuroprotective molecules contained in this medium. Here, we found that endogenous VEGF could be a good candidate for RGC neuroprotection strategies Address for correspondence: nicolas.froger@inserm.fr References 1 Fuchs C et al. (2005). Retinal-cell-conditioned medium prevents TNF-alpha-induced apoptosis of purified ganglion cells. IOVS 46:2983-2991. 2 Barres B et al. (1988) Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning. Neuron 1: 791-803. 3 Vallazza-Deschamps et al. (2005) Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors. Eur J Neurosci 22:1013-1022 4 Ruiz de Almodovar C et al. (2009) Role and therapeutic potential of VEGF in the nervous system. Physiol Rev. 89(2):607-648. |
| Databáze: | OpenAIRE |
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