Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies
| Autor: | Khalili-Mahani, N., Osch, M.J. van, Rooij, M. de, Beckmann, C.F., Buchem, M.A. van, Dahan, A., Gerven, J.M. van, Rombouts, S.A.R.B. |
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| Přispěvatelé: | Magnetic Detection and Imaging, Faculty of Science and Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
cerebral blood flow
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] resting-state networks 220 Statistical Imaging Neuroscience functional brain connectivity drug research arterial spin labeling pharmacological fMRI cerebral perfusion nervous system METIS-292329 resting state IR-83008 circulatory and respiratory physiology |
| Zdroj: | Human Brain Mapping, 35(3), 929-942 Human Brain Mapping Human brain mapping, 35(3), 929-942. Wiley-Liss Inc. Human Brain Mapping, 35, 929-42 Human Brain Mapping, 35, 3, pp. 929-42 |
| ISSN: | 1065-9471 |
| Popis: | Contains fulltext : 136087.pdf (Publisher’s version ) (Closed access) Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations--mostly in the blood oxygen level dependent (BOLD) signal--across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting-state-network consistency (RSNC)--representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)--in a crossover placebo-controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug-by-time, time, drug and physiological rates) and each of these metrics. The drug-by-time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post-hoc voxel-wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. |
| Databáze: | OpenAIRE |
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