Differences in sexual behaviour in male and female rodents: role of serotonin
| Autor: | Olivier, B., Chan, J.S., Snoeren, E.M., Olivier, J.D.A., Veening, J.G., Vinkers, C.H., Waldinger, M.D., Oosting, R.S. |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Current Topics in Behavioral Neurosciences, 8, 15-36 Current Topics in Behavioral Neurosciences, 8, pp. 15-36 |
| ISSN: | 1866-3370 |
| Popis: | Item does not contain fulltext Serotonin plays an important role in both male and female sexual behaviour. In general, reduction of 5-HT function facilitates, whereas enhancement inhibits sexual behaviour. Most fundamental research on the involvement of 5-HT in sex has been performed in rats. Selective serotonin reuptake inhibitors (SSRIs) have comparable effects on male and female sexual behaviour in rats; they inhibit it but only after chronic administration. Activation of the 5-HT(1A) receptor facilitates sexual behaviour in male rats but inhibits sexual behaviour in female rats, suggesting a differential role for 5-HT(1A) receptors in male and female rats. Research on sexual behaviour in rats with null mutations in the serotonin transporter (SERT) indicated also a differential role for 5-HT(1A) receptors in male and female sexual behaviour. Evidence exists that different pools of 5-HT(1A) receptors have differential roles in various parts of the cascade of sexual events occurring during sexual interactions. Roles for other 5-HT receptors are less well defined although 5-HT(1B), 5-HT(2A/B) and 5-HT(7) receptors seem to be involved. Identification of putative differential or comparable roles in female and male sexual activities requires more research. |
| Databáze: | OpenAIRE |
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