| Autor: |
Moore, Axel C, Hennessy, Matthew G, Nogueira, Liebert Parreiras, Franks, Susan J, Taffetani, Matteo, Seong, Hyejeong, Kang, Yoo K, Tan, Wei Shen, Miklosic, Gregor, Laham, Raya E, Zhou, Kun, Zharova, Lukeriya, King, John R, Wagner, Barbara, Haugen, Håvard Jostein, Munch, Andreas, Stevens, Molly M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| ISSN: |
1742-7061 |
| DOI: |
10.1016/j.actbio.2023.06.015 |
| Popis: |
The role of poroelasticity on the functional performance of articular cartilage has been established in the scientific literature since the 1960s. Despite the extensive knowledge on this topic there remain few attempts to design for poroelasticity and to our knowledge no demonstration of an engineered poroelastic material that approaches the physiological performance. In this paper, we report on the development of an engineered material that begins to approach physiological poroelasticity. We quantify poroelasticity using the fluid load fraction, apply mixture theory to model the material system, and determine cytocompatibility using primary human mesenchymal stem cells. The design approach is based on a fiber reinforced hydrated network and uses routine fabrication methods (electrohydrodynamic deposition) and materials (poly[ɛ-caprolactone] and gelatin) to develop the engineered poroelastic material. This composite material achieved a mean peak fluid load fraction of 68%, displayed consistency with mixture theory, and demonstrated cytocompatibility. This work creates a foundation for designing poroelastic cartilage implants and developing scaffold systems to study chondrocyte mechanobiology and tissue engineering. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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