Sclerodermatous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: incidence, predictors and outcome
| Autor: | Skert, C., Patriarca, F., Sperotto, A., Cerno, M., Filì, C., Zaja, F., Stocchi, R., Geromin, A., Daniela DAMIANI, Fanin, R. |
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| Přispěvatelé: | Skert, C, Patriarca, Francesca, Sperotto, A, Cerno, M, Fili, C, Zaja, Francesco, Stocchi, R, Geromin, A, Damiani, Daniela, Fanin, Renato |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Zdroj: | Scopus-Elsevier |
| Popis: | Scleroderma may be one of the most severe forms of chronic graft-versus-host disease (GVHD). We retrospectively evaluated its incidence, predictor variables and outcome in 133 patients who survived at least 4 months after allogeneic hematopoietic stem cell transplantation. The 5-year cumulative incidence was 15.5% in patients with chronic GVHD. The generalized form had a progressive course despite immunosuppressive therapy. Eosinophilia, autoimmune markers, and previous skin involvement by chronic GVHD with disorders of pigmentation were significantly associated with an increased probability of developing scleroderma. |
| Databáze: | OpenAIRE |
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