How do haloacetamides and haloacetic acids affect human intestinal epithelial cells?
| Autor: | Dejaeger, K, Criquet, Justine, Vanoppen, M, Cornelissen, E, Billon, G, Vignal, C |
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| Přispěvatelé: | Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), CRIQUET, JUSTINE, Dejaeger, Karlien, IWA |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
[CHIM.ANAL] Chemical Sciences/Analytical chemistry [SDE.IE]Environmental Sciences/Environmental Engineering [SDE.MCG]Environmental Sciences/Global Changes drinking water disinfection-by-products Caco-2 [SDU.ENVI] Sciences of the Universe [physics]/Continental interfaces environment [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition [SDE.MCG] Environmental Sciences/Global Changes [CHIM.ANAL]Chemical Sciences/Analytical chemistry Medicine and Health Sciences gene expression cytotoxicity [SDE.IE] Environmental Sciences/Environmental Engineering [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces environment [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | IWA 3rd international conference on disinfection and DBPs IWA 3rd international conference on disinfection and DBPs, Jun 2022, Milano, Italy IWA Disinfection and Disinfection By-Products Conference, 3rd, Abstracts 3rd IWA Specialized International Conference on Disinfection and DBPs 2022 3rd IWA Specialized International Conference on Disinfection and DBPs 2022, IWA, Jun 2022, Milan, Italy |
| Popis: | International audience; In this research, human intestinal epithelial cells (Caco-2) were exposed to haloacetamides and haloacetic acids. A 24, 48 and 72h exposure was conducted to determine the cytotoxicity of these compounds. The unregulated haloacetamides were clearly more cytotoxic than the regulated haloacetic acids. Moreover, changing the halogen from Cl to I increased the toxicity extensively. A 6h stimulation with 1 µM of each compound and subsequent RNA extraction showed high upregulation of genes involved in both oxidative stress and inflammatory pathways with haloacetamide exposure, while no significant changes were seen for haloacetic acid exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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