SERUM 25 HYDROXY VITAMIN D LEVEL RELATIONSHIP WITH KIDNEY CANCER IN NORTHERN COASTAL REGION OF CROATIA
| Autor: | Mičetić, Domagoj |
|---|---|
| Přispěvatelé: | Ćelić, Tanja, Španjol, Josip, Nadalin, Sergej, Jakovac, Hrvoje |
| Jazyk: | chorvatština |
| Rok vydání: | 2020 |
| Předmět: | |
| Popis: | Vitamin D je liposolubilan spoj čija je osnovna uloga održavanje homeostaze kalcijevih iona u organizmu. No, receptor vitamina D i enzim 1α-hidroksilaza prisutni su u mnogim tkivima što čini temelj pretpostavke, koja je in vitro i in vivo modelima i potvrđena, kako uz osnovnu postoje i druge uloge vitamina D. Prema dostupnoj literaturi jedna od njih je i antitumorska aktivnost. Cilj ovoga rada bio je istražiti postoji li povezanost i koji je oblik povezanosti između koncentracije cirkulirajućeg 25(OH)D i incidencije karcinoma bubrega. Istraživanje je obuhvatilo 227 osoba, od čega je njih 144 dijagnosticirano s karcinomom bubrega, a 83 sudionika su činila kontrolnu skupinu. Ispitanicima je imunoenzimskim testom određena serumska koncentracija 25(OH)D, a anketnim upitnikom su prikupljeni podaci koji su kasnije korišteni u regresijskim modelima prilikom statističke obrade podataka. Statističkom obradom podataka pronađen je nelinearan odnos u obliku U-krivulje između cirkulirajućeg 25(OH)D i incidencije karcinoma bubrega pri čemu je porast koncentracije do 75 nmol/L obrnuto proporcionalan s incidencijom karcinoma bubrega, a isto se ne može reći za vrijednosti više od navedene u odnosu na skupinu s vrijednostima nižim od 30 nmol/L. Rezultati prilagođenih modela za određene parametre nisu toliko uvjerljivi. Stratifikacijom podataka pokazalo se kako niske vrijednosti 25(OH)D značajno povećavaju rizik kod muškaraca. Istraživanje je pokazalo važan odnos između koncentracije cirkulirajućeg 25(OH)D i karcinoma bubrega koji se može opisati U-krivuljom premda vrijednost dobivenih rezultata svakako treba provjeriti kliničkim studijama. Vitamin D is a liposoluble compound whose primary role is maintaining the homeostasis of calcium levels in the body. However, vitamin D receptor and enzyme 1α-hydroxylase are present in many tissues, which forms the basis of the assumption, which is confirmed in in vitro and in vivo models, of additional roles of vitamin D. According to the available literature one of them is antitumor activity. The aim of this study was to determine the association and shape of that association between circulating 25(OH)D levels and the incidence of kidney cancer. 227 people were included in the study, 144 were diagnosed with kidney cancer, and remaining 83 participants formed the control group. Serum 25(OH)D was measured with an enzyme immunoassay, while other data used in regression models during statistical analysis were collected with the questionnaire. Statistical analysis revealed a non-linear association in the form of a U-shaped curve between circulating 25(OH)D levels and the incidence of kidney cancer. Incidence is reversely proportional to increasing 25(OH)D levels till the value of 75 nmol/L compared to the group with levels lower than 30 nmol/l, where there was no difference in incidence between the groups with highest and lowest levels of 25(OH)D. Results of adjusted models for certain parameters are not as conclusive. Stratification of the data showed that low values 25(OH)D significantly increased the risk in men. Research has shown an important association in form of U-shaped curve between circulating 25(OH)D and kidney cancer, although the value of the results obtained should certainly be explored by clinical trials. |
| Databáze: | OpenAIRE |
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