Simplification of HAART therapy on ambulatory HIV patients in Malaysia:a randomized controlled trial

Autor:	Velvanathan,Tineshwaran, Islahudin,Farida, Sim,Benedict L., Taha,Nur A.
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Drug Combinations Anti-Retroviral Agents Malaysia Antiretroviral Therapy Emtricitabine Highly Active Viral Load Tenofovir Benzoxazines CD4 Lymphocyte Count
Zdroj:	Pharmacy Practice (Granada), Volume: 14, Issue: 4, Article number: 830, Published: DEC 2016 Pharmacy Practice (Granada) v.14 n.4 2016 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname
Popis:	Objective: Evaluate the impact of fixed-dose combination (FDC) containing emtricitabine (FTC), tenofovir (TDF), and efavirenz (EFV) versus a free-dose combination (FRC) of the same three drugs on clinical outcomes, adherence and quality of life in Malaysian outpatients with HIV. Methods: HIV patients (n=120) on highly active antiretroviral therapy (HAART) in the infectious disease clinic of Hospital Sungai Buloh were randomized to either FDC (n=60) or FRC (n=60). Morisky scores, health-related quality of life scores and clinical outcomes such as CD4 count and viral load were assessed in both groups at baseline and six months. Result: Patients on FDC (108 SD=1.1) had a significantly higher CD4 count increase compared to the FRC group (746.1 SD=36.3 vs 799.8 SD=33.8) (p
Databáze:	OpenAIRE
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