Bleeding spectrum in children with moderate or severe von Willebrand disease: Relevance of pediatric-specific bleeding

Autor: Sanders, Yvonne, Fijnvandraat, K, Boender, Johan, Mauser-Bunschoten, EP, van der Bom, JG (Anske), de Meris, J, Smiers, FJ, Granzen, B, Brons, P, Tamminga, RYJ, Cnossen, Marjon, Leebeek, Frank
Přispěvatelé: ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology, Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9), RS: GROW - Developmental Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Hematology, Epidemiology, Pediatrics
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: American journal of hematology, 90(12), 1142-1148. Wiley-Liss Inc.
American Journal of Hematology, 90(12), 1142-1148. Wiley
American Journal of Hematology, 90(12), 1142. Wiley-Liss Inc.
American Journal of Hematology, 90(12), 1142-1148. Wiley-Liss Inc.
ISSN: 0361-8609
1096-8652
Popis: The bleeding phenotype of children with von Willebrand disease (VWD) needs to be characterized in detail to facilitate diagnosis during childhood and aid in the planning and assessment of treatment strategies. The objective was to evaluate the occurrence, type, and severity of bleeding in a large cohort of children with moderate and severe VWD. We included 113 children (aged 0-16 years) with Type 1 (n=60), 2 (n=44), and 3 (n=9) VWD with von Willebrand factor (VWF) antigen and/or VWF ristocetin cofactor levels
Databáze: OpenAIRE
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