MRI assessment of multiple dipolar relaxation time ( T 1 D ) components in biological tissues interpreted with a generalized inhomogeneous magnetization transfer (ihMT) model

Autor: Carvalho, Victor N.D., Hertanu, Andreea, Grélard, Axelle, Mchinda, Samira, Soustelle, Lucas, Loquet, Antoine, Dufourc, Erick J., Varma, Gopal, Alsop, David C., Thureau, Pierre, Girard, Olivier M., Duhamel, Guillaume
Přispěvatelé: Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Beth Israel Deaconess - Harvard Medical School, ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-17-CE18-0030,verISMO,IRM du transfert d'aimantation inhomogène : vers un nouveau biomarqueur in vivo spécifique et sensible de la myéline(2017), European Project: 713750,H2020,H2020-MSCA-COFUND-2015,DOC2AMU(2016), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Magnetic Resonance
Journal of Magnetic Resonance, 2020, 311, pp.106668. ⟨10.1016/j.jmr.2019.106668⟩
Journal of Magnetic Resonance, Elsevier, 2020, 311, pp.106668. ⟨10.1016/j.jmr.2019.106668⟩
ISSN: 1090-7807
1096-0856
DOI: 10.1016/j.jmr.2019.106668⟩
Popis: International audience; T 1D , the relaxation time of dipolar order, is sensitive to slow motional processes. Thus T 1D is a probe for membrane dynamics and organization that could be used to characterize myelin, the lipid-rich membrane of axonal fibers. A mono-component T 1D model associated with a modified ihMT sequence was previously proposed for in vivo evaluation of T 1D with MRI. However, experiments have suggested that myelinated tissues exhibit multiple T 1D components probably due to a heterogeneous molecular mobility. A bi-component T 1D model is proposed and implemented. ihMT images of ex-vivo, fixed rat spinal cord were acquired with multiple frequency alternation rate. Fits to data yielded two T 1D s of about 500 µs and 10 ms. The proposed model seems to further explore the complexity of myelin organization compared to the previously reported mono-component T 1D model.
Databáze: OpenAIRE
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