The effect of the overweight on the circulating cytokines and adipokines
| Autor: | Yetkin Ay, Zuhal, Çağlar Özşahin, Fethiye, Kumbul Doğuç, Duygu, Harun Dağdeviren, Birsen, Uskun, Ersin, Kırzıoğlu, Fatma Yeşim |
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| Rok vydání: | 2016 |
| Zdroj: | Volume: 7, Issue: 3 24-30 Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi |
| ISSN: | 2146-247X 2146-1937 |
| Popis: | Objective: Interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF-α) are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats. Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats (NH, n = 8), normal weight rats with periodontitis (NP, n = 8), overweight, periodontally healthy rats (OH, n = 8); and overweight rats with periodontitis (OP, n = 8). Periodontitis was induced by ligature for 14 days. The serum cytokine’ and adipokine’ levels were investigated using ELISA. Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats (P 0.01). Conclusions: The overweight status affected the cytokine’ and adipokine’ level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines (IL-4 and adiponectin) and higher serum levels of pro-inflammatory cytokine (IL-6) than their counterparts in normal weight rat groups. |
| Databáze: | OpenAIRE |
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