MODELLING THE INTERSTRAND CROSS-LINKS IMPACT ON DNA STRUCTURE
| Autor: | Bignon, Emmanuelle, Dršata, Tomáš, Dumont, Elise, Morell, Christophe, Lankaš, Filip |
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| Přispěvatelé: | Rayet, Béatrice, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie - UMR5182 (LC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Institut de Chimie du CNRS (INC), Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB / CAS), Czech Academy of Sciences [Prague] (CAS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
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| Zdroj: | 14th International Workshop on Radiation Damage to DNA 14th International Workshop on Radiation Damage to DNA, Mar 2016, Melbourne, Australia |
| Popis: | International audience; Interstrand cross-links are highly cytotoxic oxidatively-generated DNA lesions. They result from abasic sites (Ap) reaction with an opposite purine. The aldehyde group of the abasic site condenses with the exocyclic amino group of the purine, leading to a covalent adduct, bonding the two strands. We plan to extend the modelling to other lesions for which structure can hardly be obtained by experimental means. |
| Databáze: | OpenAIRE |
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