Chapter 20 - Hypothalamus and weight loss in amyotrophic lateral sclerosis
| Autor: | Ahmed, Rebekah, Steyn, Frederik, Dupuis, Luc |
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| Přispěvatelé: | The University of Sydney, University of Queensland [Brisbane], Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dieterle, Stéphane |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Human Hypothalamus-Middle and Posterior Region The Human Hypothalamus-Middle and Posterior Region, 180, Elsevier, pp.327-338, 2021, Handbook of Clinical Neurology, ⟨10.1016/B978-0-12-820107-7.00020-3⟩ |
| DOI: | 10.1016/B978-0-12-820107-7.00020-3⟩ |
| Popis: | International audience; Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disorder. While initially pathophysiology was thought to be restricted to motor deficits, it is increasingly recognized that patients develop prominent changes in weight and eating behavior that result from and mediate the underlying neurodegenerative process. These changes include alterations in metabolism, lipid levels, and insulin resistance. Emerging research suggests that these alterations may be mediated through changes in the hypothalamic function, with atrophy of the hypothalamus shown in both ALS patients and also presymptomatic genetic at-risk patients. This chapter reviews the evidence for hypothalamic involvement in ALS, including melanocortin pathways and potential treatment targets. |
| Databáze: | OpenAIRE |
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