Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements
| Autor: | Reed, Susan D, Guthrie, Katherine A, Newton, Katherine M, Anderson, Garnet L, Booth-LaForce, Cathryn, Caan, Bette, Carpenter, Janet S, Cohen, Lee S, Dunn, Andrea L, Ensrud, Kristine E, Freeman, Ellen W, Hunt, Julie R, Joffe, Hadine, Larson, Joseph C, Learman, Lee A, Rothenberg, Robin, Seguin, Rebecca A, Sherman, Karen J, Sternfeld, Barbara S, LaCroix, Andrea Z |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Aging Clinical Trials and Supportive Activities Reproductive Health and Childbirth menopause Cardiovascular Paediatrics and Reproductive Medicine Double-Blind Method Complementary and Alternative Medicine Clinical Research Behavioral and Social Science Humans Obstetrics & Reproductive Medicine Exercise 6.7 Physical Omega-3 Yoga Contraception/Reproduction Fatty Acids Rehabilitation Middle Aged Estrogen Treatment Outcome quality of life Hot Flashes Dietary Supplements randomized controlled trial Female Mind and Body |
| Zdroj: | American journal of obstetrics and gynecology, vol 210, iss 3 Reed, Susan D; Guthrie, Katherine A; Newton, Katherine M; Anderson, Garnet L; Booth-LaForce, Cathryn; Caan, Bette; et al.(2014). Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements. American Journal of Obstetrics and Gynecology, 210(3), 244.e1-244.e11. doi: 10.1016/j.ajog.2013.11.016. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/986228rf |
| DOI: | 10.1016/j.ajog.2013.11.016. |
| Popis: | ObjectiveThe purpose of this study was to determine the efficacy of 3 nonhormonal therapies for the improvement of menopause-related quality of life in women with vasomotor symptoms.Study designWe conducted a 12-week 3 × 2 randomized, controlled, factorial design trial. Peri- and postmenopausal women, 40-62 years old, were assigned randomly to yoga (n = 107), exercise (n = 106), or usual activity (n = 142) and also assigned randomly to a double-blind comparison of omega-3 (n = 177) or placebo (n = 178) capsules. We performed the following interventions: (1) weekly 90-minute yoga classes with daily at-home practice, (2) individualized facility-based aerobic exercise training 3 times/week, and (3) 0.615 g omega-3 supplement, 3 times/day. The outcomes were assessed with the following scores: Menopausal Quality of Life Questionnaire (MENQOL) total and domain (vasomotor symptoms, psychosocial, physical and sexual).ResultsAmong 355 randomly assigned women who average age was 54.7 years, 338 women (95%) completed 12-week assessments. Mean baseline vasomotor symptoms frequency was 7.6/day, and the mean baseline total MENQOL score was 3.8 (range, 1-8 from better to worse) with no between-group differences. For yoga compared to usual activity, baseline to 12-week improvements were seen for MENQOL total -0.3 (95% confidence interval, -0.6 to 0; P = .02), vasomotor symptom domain (P = .02), and sexuality domain (P = .03) scores. For women who underwent exercise and omega-3 therapy compared with control subjects, improvements in baseline to 12-week total MENQOL scores were not observed. Exercise showed benefit in the MENQOL physical domain score at 12 weeks (P = .02).ConclusionAll women become menopausal, and many of them seek medical advice on ways to improve quality of life; little evidence-based information exists. We found that, among healthy sedentary menopausal women, yoga appears to improve menopausal quality of life; the clinical significance of our finding is uncertain because of the modest effect. |
| Databáze: | OpenAIRE |
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