La neutrophil gelatinase-associated lipocalin, ou LCN 2, facteur d'agressivité dans le carcinome rénal à cellules claires (CRCC). [The neutrophil gelatinase-associated lipocalin, or LCN 2, marker of aggressiveness in clear cell renal cell carcinoma]
| Autor: | Perrin, Christophe, Patard, Jean-Jacques, Jouan, Florence, Collet, Nicolas, Théoleyre, Sandrine, Edeline, Julien, Zerrouki, Salim, Laguerre, Brigitte, Belaud-Rotureau, Marc-Antoine, Rioux-Leclercq, Nathalie, Vigneau, Cécile |
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| Přispěvatelé: | Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes], CHU Pontchaillou [Rennes], CRLCC Eugène Marquis (CRLCC), Service d'urologie, Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Service de néphrologie [Rennes], CHU Pontchaillou [Rennes]-Hôpital Pontchaillou-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service de Cytogénétique et de Biologie Cellulaire, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], De Villemeur, Hervé |
| Jazyk: | francouzština |
| Rok vydání: | 2011 |
| Předmět: |
MESH: Aged
MESH: Humans MESH: Middle Aged MESH: Matrix Metalloproteinase 9 [SDV.CAN]Life Sciences [q-bio]/Cancer MESH: Neoplasm Invasiveness MESH: Carcinoma Renal Cell [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology MESH: Predictive Value of Tests MESH: Prognosis MESH: Sensitivity and Specificity MESH: Male MESH: Proto-Oncogene Proteins [SDV.CAN] Life Sciences [q-bio]/Cancer MESH: Survival Analysis MESH: Tumor Markers Biological MESH: Lipocalins MESH: Acute-Phase Proteins MESH: Kidney Neoplasms MESH: Female |
| Zdroj: | Progrès en Urologie Progrès en Urologie, Elsevier Masson, 2011, 21 (12), pp.851-8. ⟨10.1016/j.purol.2011.06.005⟩ Progrès en Urologie, 2011, 21 (12), pp.851-8. ⟨10.1016/j.purol.2011.06.005⟩ |
| ISSN: | 1166-7087 2405-5131 |
| DOI: | 10.1016/j.purol.2011.06.005⟩ |
| Popis: | International audience; OBJECTIVE: To determine the prognostic significance of the neutrophil gelatinase-associated lipocalin (NGAL) and the matrix metalloproteinase 9 (MMP-9) in clear cell renal cell carcinoma (CCRCC). PATIENTS AND METHODS: NGAL and MMP-9 expression were quantified by immunohistochemistry in clear renal cell carcinoma tissues and in sera by Enzyme Linked Immunosorbent Assay (Elisa). Results were associated with clinicopathologic data. RESULTS: Seventy-four patients operated for CCRCC in Rennes between 2003 and 2009 were included. High concentrations of NGAL-MMP-9 complex in serum were associated with short progression free survival (PFS) (33.3 months versus 47.3 months, P=0.016) and poor overall survival (42.5 months versus 51.9 months, P |
| Databáze: | OpenAIRE |
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