The amniote oculomotor complex
| Autor: | Company, Verónica, Moreno-Bravo, Juan Antonio, Pérez-Balaguer, Ariadna, Puelles, Eduardo |
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| Přispěvatelé: | Instituto de Salud Carlos III, Generalitat Valenciana, Ministerio de Economía y Competitividad (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The oculomotor (OM) complex is a combination of somatic and parasympatethic neurons. The correct development and wiring of this cranial pair is essential to perform basic functions: eyeball and eyelid movements, pupillary constriction, and lens accommodation. The improper formation or function of this nucleus leads pathologies such as strabismus. We describe the OM organization and function in different vertebrate brains, including chick, mouse, and human. The morphological localization is detailed, as well as the spatial relation with the trochlear nucleus in order to adjust some misleading anatomical topographic descriptions. We detailed the signaling processes needed for the specification of the OM neurons. The transcriptional programs driven the specification and differentiation of these neurons are partially determined. We summarized recent genetic studies that have led to the identification of guidance mechanisms involved in the migration, axon pathfinding, and targeting of the OM neurons. Finally, we overviewed the pathology associated to genetic malformations in the OM development and related clinical alterations. Grant sponsors: Ministerio de Ciencia e Innovacion (FEDER); Grant number: BFU2013-48230; GENERALITAT VALENCIANA (FEDER); Grant number: PROMETEOII/2014/014; Red de Terapia Celular (FEDER); Grant number: RD16/ 001/0010; Ministerio de Educacion, Cultura y Deporte (FPU program); Grant number: FPU16/03853 |
| Databáze: | OpenAIRE |
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