Effects of Vitamin E Deficiency on 1,2-Dimethylhydrazine-Induced Intestinal Carcinogenesis in Rats
| Autor: | SUMIYOSHI, Hiromichi |
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| Jazyk: | angličtina |
| Rok vydání: | 1985 |
| Předmět: | |
| Zdroj: | Hiroshima Journal of Medical Sciences. 34(3):363-369 |
| Popis: | The effects of vitamin E deficiency on intestinal carcinogenesis and intestinal epithelial cell kinetics were investigated in male Wistar strain rats treated with 1,2-dimethylhydrazine (DMH) dihydrochloride. In the time course study of intestinal tumors induced by DMH (20 mg/kg, 20 weekly s.c. injections), at the early stage when no intestinal tumor was observed in control rats, tumor-bearing rats were detected in the vitamin E deficient group. Moreover, in rats treated with DMH (20 mg/kg, 3 weekly s.c. injections) after vitamin E deficient status, the incidence of rats with intestinal tumors was significantly higher in the vitamin E deficient group (58.3 %) than in the sufficient group (8.3 %) at 15 weeks after DMH treatment (p Some sections of this manuscript were presented at the 73rd Annual Congress of the Japanese Pathological Society, April 3-5, 1984, Tokyo and the third International Congress on Cell Biology, August 26-31, 1984, Tokyo, Japan. |
| Databáze: | OpenAIRE |
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