Human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals

Autor: Boxman, Ingeborg L.A., Mulder, L.H.C., Russell, A., Bouwes Bavinck, J.N., Green, A., Ter Schegget, J.
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Zdroj: British journal of dermatology, 141(2), 246-249
British journal of dermatology 141 (1999) 2
ISSN: 0007-0963
Popis: DNA of a wide spectrum of epidermodysplasia verruciformis-associated human papillomavirus (HPV) types (EV-HPV) has been detected in skin lesions and plucked hairs from both immunosuppressed and a considerable proportion of non-immunosuppressed persons. Recently, the skin of psoriatic patients was claimed to be an important reservoir for a particular EV-HPV type, HPV 5, which is considered as a high-risk HPV type for skin carcinomas. In the present study, we analysed plucked hairs from immunosuppressed renal transplant patients and immunocompetent individuals, utilizing an HPV 5- specific nested polymerase chain reaction. HPV 5 was detected in hairs derived from 14 of 31 (45%) immunosuppressed patients and 21 of 135 (16%) immunocompetent individuals. Both the immunosuppressed and the immunocompetent groups consisted of individuals with and without non-melanoma skin cancer. HPV 5 DNA was detected in similar proportions of hair samples plucked from individuals with and without skin cancer in either group. Our results indicate that HPV 5 is commonly present in the population. The role of HPV 5 in the pathogenesis of skin carcinomas and psoriasis remains to be established.
Databáze: OpenAIRE
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