Alterations of negative regulators of cytokine signalling in immunodeficiency-related non-Hodgkin lymphoma

Autor: Capello, Daniela, Gloghini, Annunziata, Baldanzi, Gianluca, Martini, Maurizio, Deambrogi, Clara, Lucioni, Marco, Piranda, Daniela, Famà, Rosella, Graziani, Andrea, Spina, Michele, Tirelli, Umberto, Paulli, Marco, Larocca Luigi Maria, Gaidano, Gianluca, Carbone, Antonino, Sinigaglia, Fabiola
Přispěvatelé: Capello, Daniela, Gloghini, Annunziata, Baldanzi, Gianluca, Martini, Maurizio, Deambrogi, Clara, Lucioni, Marco, Piranda, Daniela, Famà, Rosella, Graziani, Andrea, Spina, Michele, Tirelli, Umberto, Paulli, Marco, Larocca, Luigi Maria, Gaidano, Gianluca, Carbone, Antonino, Sinigaglia, Fabiola
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Cancer Research
Lymphoma
DNA Mutational Analysis
Suppressor of Cytokine Signaling Proteins
STAT Transcription Factor
Cell Line
Clonal Evolution
DNA Mutational Analysi
Neoplasm Protein
Immunodeficiency
PTPN6/SHP1
SOCS1
SOCS3
Tumor
Cytokines
DNA
Neoplasm
Humans
Immunocompromised Host
Janus Kinases
AIDS-Related
Lymphoproliferative Disorders
Mutation
Neoplasm Proteins
Organ Transplantation
Postoperative Complications
Protein Tyrosine Phosphatase
Non-Receptor Type 6
Retrospective Studies
STAT Transcription Factors
Signal Transduction
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling 3 Protein
DNA Methylation
Hematology
Oncology
Retrospective Studie
Cell Line
Tumor
Suppressor of Cytokine Signaling Protein
Cytokine
Lymphoma
AIDS-Related
Protein Tyrosine Phosphatase
Non-Receptor Type 6
DNA
Neoplasm
Lymphoproliferative Disorder
Janus Kinase
Postoperative Complication
Human
Popis: We investigated immunodeficiency-related non-Hodgkin lymphoma for the presence of molecular alterations affecting negative regulators of the Janus family protein tyrosine kinase/signal transducer and activator of transcription pathway. Protein tyrosine phosphatase, non-receptor type 6/Src homology 2-containing tyrosine phosphatase-1 epigenetic silencing was recurrent in primary effusion lymphoma (100%), and diffuse large B-cell lymphoma (63%), with a higher prevalence in the non-germinal centre subtype, and was associated with the activation of the Janus family protein tyrosine kinase/signal transducer and activator of transcription 3 pathway. Suppressor of cytokine signalling (SOCS)1 and SOCS3 epigenetic silencing were occasionally detected, whereas SOCS1 was frequently mutated in diffuse large B-cell lymphoma and polymorphic post-transplant lymphoproliferative disorders, possibly as a cause of aberrant somatic hypermutation. However, the mutation profile of the coding region of the gene was different from that expected from the aberrant somatic hypermutation process, suggesting that, at least in some cases, SOCS1 mutations may have been selected for their functional activity. © 2012 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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