Cumulative exposure to tacrolimus and incidence of cancer after liver transplantation

Autor: Rodríguez-Perálvarez M, Colmenero J, González A, Gastaca M, Curell A, Caballero-Marcos A, Sánchez-Martínez A, Di Maira T, Herrero JI, Almohalla C, Lorente S, Cuadrado-Lavín A, Pascual S, López-Garrido MÁ, González-Grande R, Gómez-Orellana A, Alejandre R, Zamora J, Bernal-Bellido C
Rok vydání: 2022
Předmět:
Zdroj: AMERICAN JOURNAL OF TRANSPLANTATION
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
ISSN: 1600-6135
Popis: Cancer is the leading cause of death after liver transplantation (LT). This multicenter case-control nested study aimed to evaluate the effect of maintenance immunosuppression on post-LT malignancy. The eligible cohort included 2,495 LT patients who received tacrolimus-based immunosuppression. After 13,922 person/years follow-up, 425 patients (19.7%) developed malignancy (cases) and were matched with 425 controls by propensity score based on age, gender, smoking habit, etiology of liver disease and hepatocellular carcinoma (HCC) before LT. The independent predictors of post-LT malignancy were older age (HR=1.06 [95%CI 1.05-1.07]; p
Databáze: OpenAIRE
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