High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults
| Autor: | Rezk-Hanna, Mary, Mosenifar, Zab, Benowitz, Neal L, Rader, Florian, Rashid, Mohamad, Davoren, Katherine, Moy, Norma B, Doering, Lynn, Robbins, Wendie, Sarna, Linda, Li, Ning, Chang, L Cindy, Elashoff, Robert M, Victor, Ronald G |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nicotine Drug Abuse (NIDA Only) Pediatric Research Initiative Brachial Artery Adolescent Clinical Sciences Water Pipe Smoking smoking water pipes Cardiorespiratory Medicine and Haematology Cardiovascular tobacco carbon monoxide Heating Young Adult Clinical Research Vascular Humans Endothelium Cancer waterpipe Tobacco Smoke and Health Prevention Angioplasty Substance Abuse Good Health and Well Being Cardiovascular System & Hematology Regional Blood Flow Charcoal Respiratory Public Health and Health Services Female vascular endothelium Balloon |
| Zdroj: | Rezk-Hanna, Mary; Mosenifar, Zab; Benowitz, Neal L; Rader, Florian; Rashid, Mohamad; Davoren, Katherine; et al.(2019). High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults.. Circulation, 139(19), 2215-2224. doi: 10.1161/circulationaha.118.037375. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/3745p27w Circulation, vol 139, iss 19 |
| ISSN: | 0361-6002 |
| Popis: | BackgroundHookah smoking is marketed to youth as a harmless alternative to cigarettes. Although cigarette smoking acutely impairs endothelial function, the effect of smoking fruit-flavored hookah tobacco is unknown. Because charcoal traditionally is used to heat the hookah tobacco in the waterpipe, hookah smoke delivers tobacco toxicants and nicotine plus charcoal combustion products: not only carbon-rich nanoparticles, oxidants that may destroy nitric oxide and impair endothelial function, but also large amounts of carbon monoxide (CO), a putative vasodilator molecule.MethodsTo test the acute effect of hookah smoking on endothelial function, in young adult hookah smokers (n=30, age 26±1 years, mean±SE), we measured plasma nicotine, exhaled CO, and brachial artery flow-mediated dilation (FMD) before and after charcoal-heated hookah smoking. To remove the effect of charcoal combustion, the same measurements were performed when the same flavored hookah tobacco product was heated electrically (n=20). As a positive internal control, we studied age-matched cigarette smokers (n=15) who smoked 1 cigarette. To isolate the effect of the CO boost on FMD, hookah smokers (n=8) inhaled a 0.1% CO gas mixture to approximate their CO boost achieved with charcoal-heated hookah smoking.ResultsNicotine levels increased similarly with all types of smoking, whereas exhaled CO increased 9- to 10-fold more after charcoal-heated hookah than after either electrically heated hookah or cigarette smoking. FMD did not decrease after smoking charcoal-heated hookah but instead increased by +43±7% ( P |
| Databáze: | OpenAIRE |
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