Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Autor: Fairfoul G, Li, Mcguire, Pal S, James Ironside, Neumann J, Christie S, Joachim C, Esiri M, Sg, Evetts, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Mt, Hu, Parkkinen L, Aj, Green
Rok vydání: 2016
Předmět:
Zdroj: Fairfoul, G, McGuire, L I, Pal, S, Ironside, J W, Neumann, J, Christie, S, Joachim, C, Esiri, M, Evetts, S G, Rolinski, M, Baig, F, Ruffmann, C, Wade-Martins, R, Hu, M T M, Parkkinen, L & Green, A J E 2016, ' Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies ', Annals of Clinical and Translational Neurology, vol. 3, no. 10, pp. 812-818 . https://doi.org/10.1002/acn3.338
Fairfoul, G, McGuire, L I, Pal, S, Ironside, J, Neumann, J, Christie, S, Joachim, C, Esiri, M, Evetts, S G, Rolinski, M, Baig, F, Ruffmann, C, Wade-Martins, R, Hu, M T M, Parkkinen, L & Green, A 2016, ' Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies ', Annals of Clinical and Translational Neurology . https://doi.org/10.1002/acn3.338
Europe PubMed Central
ISSN: 2328-9503
DOI: 10.1002/acn3.338
Popis: We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies.
Databáze: OpenAIRE
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