Comparison of 68Ga-PSMA-I/T PET-CT and Multiparametric MRI for Locoregional Staging of Prostate Cancer Patients: A Pilot Study
| Autor: | Çelen, Sinan, Gültekin, Aziz, Özlülerden, Yusuf, Mete, Aslı, Saǧtaş, Ergin, Ufuk, Furkan, Yüksel, Doğangün, Yaǧcl, Baki, Zümrütbaş, Ali Ersin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
gallium 68
urologic and male genital diseases postoperative period Article male image analysis diagnostic test accuracy study human seminal vesicle preoperative period comparative study clinical article Prostate cancer lymph node metastasis predictive value prostatectomy adult cancer staging pilot study single drug dose prostate specific membrane antigen tumor invasion bladder neck multiparametric magnetic resonance imaging laparoscopic surgery human tissue 68Ga-PSMA-I/T PET-CT aged priority journal mp-MRI sensitivity and specificity histopathology positron emission tomography-computed tomography diagnostic accuracy diagnostic value |
| Popis: | Background/Aim: The objective of this work was to assess the value of 68Ga-DOTAGA-(3-iodo-y)fk(Sub-KuE) positron emission tomography (68Ga-PSMA-I/T PET-CT) and multiparametric magnetic resonance imaging (mp-MRI) for preoperative staging in prostate cancer (PCa) patients who underwent radical prostatectomy (RP) by validating with postoperative histopathology data. Materials and Methods: We prospectively investigated 30 consecutive PCa patients who had both mp-MRI and 68Ga-PSMA-I/T PET-CT before laparoscopic RP. The seminal vesicle invasion (SVI), lymph node metastasis (LNM), bladder neck invasion (BNI), and extracapsular extension (ECE) were investigated separately. The diagnostic performances of mp-MRI and 68Ga-PSMA-I/T PET-CT were assessed using histopathological results. Results: Both mp-MRI and 68Ga-PSMA-I/T PET-CT were not statistically significant in the evaluation of SVI, BNI, and ECE preoperatively but had statistically significant results in the assessment of LNM. mp-MRI had higher overall sensitivity for ECE, overall specificity for SVI, ECE, and BNI, and positive predictive value for ECE, SVI, BNI. 68Ga-PSMA-I/T PET-CT had higher overall sensitivity for BNI, and negative predictive value for BNI and LNM. Conclusion: mp-MRI has superior specificity, sensitivity, and accuracy for assessing ECE and SVI. Both imaging modalities had similar specificity, sensitivity, and accuracy for determining BNI. However, both imaging modalities had low diagnostic accuracy for LNM on histopathology. © 2020 S. Karger AG, Basel. Copyright: All rights reserved. |
| Databáze: | OpenAIRE |
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