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CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Mgr. Tereza Neuwirthová Title of thesis: Polymeric systems with aciclovir for mucosal application Consultant: PharmDr. Eva Šnejdrová, Ph.D. Rigorous work deals with incorporation of aciclovir in the polyester of lactic and glycolic acid branched with 3% tripenthaerythritol (PLGA/3T) and plasticized with ethyl salicylate (ES). Theoretical part is focused on the using of ACV in topic preparations, on the methods of drug incorporation into the polymers, on the interactions between polymer and drug, and possibilities of drug solubility increasing by formation of solid dispersion systems and possibilities of using polyesters of lactic and glycolic acid in pharmacy and medicine. Experimental part covers thermal analysis of ACV, PLGA/3T, polyester PLGA/3T with 5% ACV and polyester PLGA/3T plasticized with 20% and 30% ES. Tg value of PLGA/3T with 5% ACV shows on formation of solid dispersed system with ACV and absence of ACV in crystalline form. The ACV release from polyesters PLGA/3T plasticized with 20% and 30% ES was studied. The 24-hours burst effect was approximately 20%, followed by linear release of ACV by zero order kinetics until the 25th day. The viscosity of PLGA/3T plasticized... |
