The contrOL of dYslipideMia in outPatIent clinics in GreeCe (OLYMPIC) study
| Autor: | Diamantopoulos, E. J., Athyros, V. G., Yfanti, G. K., Migdalis, E. N., Elisaf, M., Vardas, P. E., Manolis, A. S., Karamitsos, D. T., EMMANUEL GANOTAKIS, Hatseras, D. |
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| Předmět: |
Adult
Exercise Male Hypolipidemic Agents/*therapeutic use Greece Diet Fat-Restricted Coronary Artery Disease/etiology/prevention & control Middle Aged Ambulatory Care Facilities Risk Assessment Treatment Outcome Cholesterol LDL/blood Humans Patient Compliance Female Dyslipidemias/blood/complications/*therapy Risk Reduction Behavior Aged Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| Popis: | The objective of this study was to determine the proportion of Greek patients referred to outpatient clinics for dyslipidemia who achieved the low-density lipoprotein cholesterol (LDL-C) goal defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guidelines, using lifestyle changes, lipid-lowering drug treatment (LLDT), or both. Adult patients with dyslipidemia, who had been receiving a hypolipidemic diet and/or LLDT for at least 3 months were assessed in a multicenter study performed at 66 sites across Greece. Patients were followed up for an additional 3-month treatment period. Lipid levels were recorded at baseline and at the end of the study. The primary endpoint was the proportion of patients achieving their individual LDL-C target at the end of the study, according to their coronary heart disease (CHD) risk status or its equivalents, as defined by the NCEP-ATP III guidelines. Multivariate logistic models were used to identify determinants of undertreatment. The study included 2,660 adults (20-75 years) from 7 regions of Greece. Of the evaluable sample (n = 2,211; men 51%; mean age 62 +/-9 years) 81% were receiving LLDT (96% with statins and 3% with fibrates), 44% had a history of CHD, 61% arterial hypertension, 36% diabetes, and 26% a family history of premature CHD. Overall, 6% were at low CHD risk, 30% at medium CHD risk, and 63% at high CHD risk. At the end of the study, 26% of all patients and 30% of those receiving LLDT achieved the NCEP-specified LDL-C target levels. The percentage of patients at LDL-C goal according to CHD risk status was: low risk 67% (95% CI = 59-75), medium risk 29% (95% CI = 26-33), and high risk 20% (95% CI = 18-22). Statins proved to be more effective than fibrates (p |
| Databáze: | OpenAIRE |
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