Identification of novel epithelial ovarian cancer loci in women of African ancestry

Autor: Manichaikul, Ani, Peres, Lauren C, Wang, Xin-Qun, Barnard, Mollie E, Chyn, Deanna, Sheng, Xin, Du, Zhaohui, Tyrer, Jonathan, Dennis, Joseph, Schwartz, Ann G, Cote, Michele L, Peters, Edward, Moorman, Patricia G, Bondy, Melissa, Barnholtz-Sloan, Jill S, Terry, Paul, Alberg, Anthony J, Bandera, Elisa V, Funkhouser, Ellen, Wu, Anna H, Pearce, Celeste Leigh, Pike, Malcom, Setiawan, Veronica Wendy, Haiman, Christopher A, African American Breast Cancer Consortium (AABC), African Ancestry Prostate Cancer Consortium (AAPC), Palmer, Julie R, LeMarchand, Loic, Wilkens, Lynne R, Berchuck, Andrew, Doherty, Jennifer A, Modugno, Francesmary, Ness, Roberta, Moysich, Kirsten, Karlan, Beth Y, Whittemore, Alice S, McGuire, Valerie, Sieh, Weiva, Lawrenson, Kate, Gayther, Simon, Sellers, Thomas A, Pharoah, Paul, Schildkraut, Joellen M, African American Cancer Epidemiology Study (AACES) and the Ovarian Cancer Association Consortium (OCAC)
Přispěvatelé: Peres, Lauren C [0000-0002-6620-8600], Du, Zhaohui [0000-0002-7125-8928], Barnholtz-Sloan, Jill S [0000-0001-6190-9304], Pearce, Celeste Leigh [0000-0002-8023-7846], Pike, Malcom [0000-0003-4891-1199], Modugno, Francesmary [0000-0003-0637-1534], Lawrenson, Kate [0000-0002-6469-2515], Schildkraut, Joellen M [0000-0002-0990-9339], Apollo - University of Cambridge Repository
Rok vydání: 2020
Předmět:
Follistatin
endocrine system diseases
Oncology and Carcinogenesis
Black People
Breast Neoplasms
Carcinoma
Ovarian Epithelial
Polymorphism
Single Nucleotide
African Ancestry Prostate Cancer Consortium
White People
Rare Diseases
Antigens
Neoplasm
Clinical Research
Ovarian Epithelial
Genetics
Humans
2.1 Biological and endogenous factors
Genetic Predisposition to Disease
Oncology & Carcinogenesis
Antigens
Polymorphism
Aetiology
genome wide association study
Cancer
eQTLs
Prevention
Carcinoma
Aldo-Keto Reductase Family 1 Member C3
African American Cancer Epidemiology Study (AACES) and the Ovarian Cancer Association Consortium
African American Breast Cancer Consortium
Single Nucleotide
United States
Neoplasm Proteins
Ovarian Cancer
Black or African American
ovarian cancer
African ancestry
gene expression
Neoplasm
Female
Genome-Wide Association Study
Biotechnology
Zdroj: International journal of cancer, vol 146, iss 11
Popis: Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p
Databáze: OpenAIRE
Externí odkaz: