Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation
| Autor: | Paolo Marizza, Stephan Sylvest Keller, Rades, T., Müllertz, A., Kikic, I., Moneghini, M., Zordi, N., Solinas, D., Anja Boisen |
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| Přispěvatelé: | CRS, P., Marizza, S. S., Keller, T., Rade, A., Müllertz, Kikic, Ireneo, Moneghini, Mariarosa, DE ZORDI, Nicola, Solinas, Dario, A., Boisen |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Technical University of Denmark Orbit |
| Popis: | In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release. Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams. |
| Databáze: | OpenAIRE |
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