First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination?
| Autor: | Vieira-Gonçalves, Ricardo, Fagundes-Silva, Giselle Aparecida, Heringer, Júlia Furtado, Fantinatti, Maria, Da-Cruz, Alda Maria, Oliveira-Neto, Manoel Paes, Guerra, Jorge Augusto Oliveira, Gomes-Silva, Adriano |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
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| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.52 2019 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Volume: 52, Article number: e20180323, Published: 11 APR 2019 |
| Popis: | We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. However, after pentamidine treatment, this patient’s infection evolved to therapeutic failure. To understand this clinical outcome, we investigated the presence of the Leishmania RNA virus (LRV) in parasites isolated from the cutaneous lesion; herein, we discuss the possible association between a poor response to pentamidine therapy and the presence of the LRV. |
| Databáze: | OpenAIRE |
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