Both early and late apoptotic blebs are taken up by DC and induce IL-6 production
| Autor: | Fransen, J.H., Hilbrands, L.B., Jacobs, C.W.M., Adema, G.J., Berden, J.H.M., Vlag, J. van der |
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| Rok vydání: | 2009 |
| Předmět: |
surgical procedures
operative genetic structures Immune Regulation [NCMLS 2] Translational research [ONCOL 3] lipids (amino acids peptides and proteins) sense organs Tissue engineering and pathology [NCMLS 3] Auto-immunity transplantation and immunotherapy [N4i 4] Infection and autoimmunity [NCMLS 1] eye diseases |
| Zdroj: | Autoimmunity, 42, 325-7 Autoimmunity, 42, 4, pp. 325-7 |
| ISSN: | 0891-6934 |
| Popis: | Contains fulltext : 80827.pdf (Publisher’s version ) (Closed access) During apo blebs, containing nuclear components, are formed at the cells' surfaces. When these blebs separate from the dying cell an apo cell body remains. The contents of apo blebs are modified and can be released, especially in patients with systemic lupus erythematosus (SLE) since impaired clearance of apo material has been observed in this autoimmune condition. Accordingly, autoantibodies present in subjects with SLE bind to apo blebs. Based on AnxA5 binding, and permeability for PI, we show that apo blebs can be categorized as early (AnxA5(+)/PI(- )) or late (AnxA5(+)/PI(+)) apo ones. Both forms of blebs contain apo-induced chromatin modifications and are efficiently phagocytosed by dendritic cell (DC). Uptake by DC of late, but also early apo blebs, stimulate DC to produce IL-6. This bleb-induced effect on DC may be an important step in the initiation of the autoimmune responses in SLE. |
| Databáze: | OpenAIRE |
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