New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and on dimorphic Arxula adeninivorans and Yarrowia lipolytica - A comparison

Autor: Gellissen, Gerd, Gaillardin, Claude, Kunze, Gotthard, Cregg, James, Berardi, Enrico, Veenhuis, Marten, Van Der Klei, Ida
Přispěvatelé: GBB Cluster Microbiologie, Moleculaire Celbiologie, Faculty of Science and Engineering, Groningen Biomolecular Sciences and Biotechnology, PharmedArtis Gmbh, Partenaires INRAE, Microbiologie et Génétique Moléculaire (MGM), Institut National de la Recherche Agronomique (INRA)-Institut National Agronomique Paris-Grignon (INA P-G)-Centre National de la Recherche Scientifique (CNRS), Institut National Agronomique Paris Grignon (INAPG), Institut für Plfanzengenetik und Kulturpflanzenforschung, Keck Graduate Institute [Claremont, Californie] (KGI), Università degli studi di Paavia, Eukaryotic Microbiology
Jazyk: Dutch; Flemish
Rok vydání: 2005
Předmět:
Zdroj: Fems Yeast Research, 5(11), 1079-1096
FEMS Yeast Research
FEMS Yeast Research, Oxford University Press (OUP), 2005, 5 (11), pp.1079-1096. ⟨10.1016/j.femsyr.2005.06.004⟩
ISSN: 1567-1356
1567-1364
Popis: International audience; Yeasts combine the ease of genetic manipulation and fermentation of a microbial organism with the capability to secrete and to modify proteins according to a general eukaryotic scheme. Yeasts thus provide attractive platforms for the production of recombinant proteins. Here, four important species are presented and compared: the methylotrophic Hansenula polymorpha and Pichia pastoris, distinguished by an increasingly large track record as industrial platforms, and the dimorphic species Arxula adeninivorans and Yarrrowia lipolytica, not yet established as industrial platforms, but demonstrating promising technological potential, as discussed in this article.
Databáze: OpenAIRE
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