Knee radiosynovectomy with Sm-153-hydroxyapatite compared to Y-90-hydroxyapatite : initial results of a prospective trial
| Autor: | Santos, Allan de Oliveira, 1971, Ricciardi, Janaina Bosso da Silva, Pagnano, Rodrigo Gonçalves, 1967, Pereira, Luís Fernando Moreno, 1987, Sakuma, Emerson Taro Inoue, 1977, Brunetto, Sérgio Querino, 1955, Takahashi, Maria Emilia Seren, 1985, Brunetto, Edna Marcia Rodrigues, Zulli, Roberto, Ozelo, Margareth Castro, 1970, Etchebehere, Elba Cristina Sa de Camargo, 1967 |
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| Přispěvatelé: | UNIVERSIDADE ESTADUAL DE CAMPINAS |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Unicamp Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP Repositório da Produção Científica e Intelectual da Unicamp |
| Popis: | Agradecimentos: We thank the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP # 2013/05255-7) for partial financing of this investigation. We also thank Efrain Perini (PhD) and Jair Mengatti (PhD) from the Radiopharmacy Center of the Nuclear and Energy Research Institute (IPEN/CNEN), São Paulo, Brazil Abstract: Introduction Radiosynovectomy (RS) with Y-90-hydroxyapatite (Y-90-HyA) aims to control knee hemarthrosis in hemophiliac patients to prevent secondary arthropathy. However, knee RS using Sm-153-hydroxyapatite (Sm-153-HyA) is considered less suitable due to the lower average soft tissue range and energy of Sm-153 for large joints, such as the knees. Purpose The objective of this investigation was to assess the efficacy and safety of knee RS with Sm-153-HyA, compared to Y-90-HyA. Methods Forty patients were prospectively assigned to undergo knee RS with Sm-153-HyA (n = 19) or with Y-90-HyA (n = 21). The frequency of hemarthrosis episodes before and after treatment were compared. Results After six months of knee RS, Sm-153-HyA and Y-90-HyA promoted a similar reduction of hemarthrosis episodes (50% and 66.7%, respectively). However, after 12 months of knee RS, the reduction of hemarthrosis episodes was significantly (p = 0.037) higher using Sm-153-HyA (87.5%) compared to Y-90-HyA (50.0%). This discrepancy was more pronounced (p = 0.002) for Sm-153-HyA compared to Y-90-HyA in adults/adolescents. Conclusion Knee radiosynovectomy with Sm-153-HyA is safe, reduces hemarthrosis episodes after 12 months of treatments, especially in adults/adolescents and even with grades III/IV arthropathy, similar to Y-90-HyA. Y-90-HyA seems to promote better hemarthrosis control in small children FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP Fechado |
| Databáze: | OpenAIRE |
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