| Autor: |
Williams, MC, Hunter, A, Shah, A, Assi, V, Lewis, S, Mangion, K, Berry, C, Boon, NA, Clark, E, Flather, M, Forbes, J, McLean, S, Roditi, G, van Beek, EJ, Timmis, AD, Newby, DE, Scottish COmputed Tomography of the HEART (SCOT-HEART) Trial Inv |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| ISSN: |
1468-201X |
| Popis: |
BACKGROUND: In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown. METHODS: In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA. Symptoms and quality of life were assessed over 6 months using the Seattle Angina Questionnaire and Short Form 12. RESULTS: Baseline scores indicated mild physical limitation (74±0.4), moderate angina stability (44±0.4), modest angina frequency (68±0.4), excellent treatment satisfaction (92±0.2) and moderate impairment of quality of life (55±0.3). Compared with standard care alone, CTCA was associated with less marked improvements in physical limitation (difference -1.74 (95% CIs, -3.34 to -0.14), p=0.0329), angina frequency (difference -1.55 (-2.85 to -0.25), p=0.0198) and quality of life (difference -3.48 (-4.95 to -2.01), p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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