| Autor: |
Muema, DM, Nduati, EW, Uyoga, M, Bashraheil, M, Scott, JAG, Hammitt, LL, Urban, BC |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| ISSN: |
0009-9104 |
| Popis: |
Memory B cells are long-lived and could contribute to persistence of humoral immunity by maintaining the plasma-cell pool or making recall responses upon re-exposure to an antigen. We determined the ability of a pneumococcal conjugate vaccine to induce anti-pneumococcal memory B cells. Frequencies of memory B cells against pneumococcal capsular polysaccharides from serotypes 1, 6B, 14, 19F and 23F were determined by cultured B cell enzyme-linked immunospot (ELISPOT) in 35 children aged 12-23 months who received pneumococcal non-typeable Haemophilus influenzae protein-D conjugate vaccine (PHiD-CV). The relationships between plasma antibodies and memory B cell frequencies were also assessed. After two doses of PHiD-CV, the proportion of subjects with detectable memory B cells against pneumococcal capsular polysaccharides increased significantly for serotypes 1 (3-45%; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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