| Autor: |
Matthai, William H, Kurnik, Peter B, Groh, William C, Untereker, William J, Siegel, Jamie E |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American College of Cardiology. (5):1248-1256 |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/S0735-1097(98)00696-2 |
| Popis: |
OBJECTIVESThis study evaluated changes in antithrombin (AT) activity around the time of percutaneous transluminal coronary revascularization (PTCR) with unfractionated heparin anticoagulation and the effects these changes had on major thrombotic complications of PTCR.BACKGROUNDHeparin is used during PTCR to prevent thrombosis. However, heparin, a cofactor for AT, causes AT activity to fall. AT activity 20 h after heparin discontinuation. Pre-PTCR use of heparin led to lower AT activity in proportion to duration of heparin use. There was no relationship between AT activity and restenosis.CONCLUSIONSLow AT activity may contribute to major thrombotic complications of PTCR. The way heparin is used before and after PTCR is important to development of low AT activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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