MED1101: A new dialdehydic compound regulating P2×7 receptor cell surface expression in U937 cells
| Autor: | Muzzachi S, Blasi A, Ciani E, Favia M, Cardone RA, Marzulli D, Reshkin SJ, Merizzi G, Casavola V, Soleti A, Guerra L. |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Biology of the cell (Online) 105 (2013): 1–15. info:cnr-pdr/source/autori:Muzzachi S, Blasi A, Ciani E, Favia M, Cardone RA, Marzulli D, Reshkin SJ, Merizzi G, Casavola V, Soleti A, Guerra L./titolo:MED1101: A new dialdehydic compound regulating P2×7 receptor cell surface expression in U937 cells/doi:/rivista:Biology of the cell (Online)/anno:2013/pagina_da:1/pagina_a:15/intervallo_pagine:1–15/volume:105 |
| Popis: | P2×7R is a member of the ionotropic family of purinergic receptors activated by millimolar concentrations of extracellular ATP such as induced by inflammatory stimuli. The receptor is widely expressed in cells of haematopoietic origin such as monocytes, macrophages and microglia. There is growing interest in anta-gonist compounds of the P2×7R since it has been demonstrated to be a viable therapeutic target for inflammatory diseases. Here, we tested the possible P2×7 antagonist effect of MED1101, a newly synthesised dialdehydic compound on U937 monocyte cells. |
| Databáze: | OpenAIRE |
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