IL-18 in autoimmunity
| Autor: | Boraschi D, Dinarello CA |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | European cytokine network (Montrouge) 17 (2006): 224–252. info:cnr-pdr/source/autori:Boraschi D, Dinarello CA/titolo:IL-18 in autoimmunity/doi:/rivista:European cytokine network (Montrouge)/anno:2006/pagina_da:224/pagina_a:252/intervallo_pagine:224–252/volume:17 |
| Popis: | IL-18 is among the cytokines responsible for immune-mediated pathologies and is probably one of the factors that contribute to the pathogenesis of autoimmune diseases. Identification of the causes of uncontrolled IL-18 production and activity in autoimmunity would allow for novel therapeutic targets to effectively block autoimmune activation and inhibit concomitant tissue damage. IL-18 is produced mainly by monocytes/macrophages in response to stimuli of viral/bacterial origin, its production being therefore one of the effects of innate immunity initiated by host-pathogen interaction. In this review, we summarise the evidence supporting both the effector and the pathogenic role of IL-18 in autoimmunity, and propose that the disturbed mechanism of innate immunity, resulting from macrophage activation through innate immunity receptors (TLR/IL-1R family), may be the basis of pathologically high levels of IL-18 production and activation. Unravelling the mechanisms of IL-18 production and activity in autoimmune diseases will allow the identification of targets for more effective therapeutic intervention. |
| Databáze: | OpenAIRE |
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