EPIDEMIOLOGICAL SURVEY OF OSTEOPOROSIS IN A GENETIC ISOLATE OF OGLIASTRA AS A PREREQUISITE FOR IDENTIFICATION OF PREDISPOSING RISK FACTORS

Autor: G Biino, L Casula, F de Terlizzi, M Adamo, D Serra, M Cosso, G Mancosu, M Francavilla, G Tuligi, F Piras, A Angius, M Pirastu
Jazyk: angličtina
Rok vydání: 2006
Zdroj: VII Congresso Nazionale della Società Italiana dell’Osteoporosi, SIOMMMS, pp. 325–326, Pisa, 22-25 novembre2006
info:cnr-pdr/source/autori:G Biino, L Casula, F de Terlizzi, M Adamo, D Serra, M Cosso, G Mancosu, M Francavilla, G Tuligi, F Piras, A Angius, M Pirastu/congresso_nome:VII Congresso Nazionale della Società Italiana dell’Osteoporosi, SIOMMMS/congresso_luogo:Pisa/congresso_data:22-25 novembre2006/anno:2006/pagina_da:325/pagina_a:326/intervallo_pagine:325–326
Popis: As part of the Ogliastra project, which focuses on the study of the genealogy, genetics and clinical features of isolated populations in this area of Sardinia, we conducted a transversal epidemiological study to estimate the prevalence, the environmental determinants and heredibility of osteoporosis in Baunei (n=3800). This village has historically been geographically isolated, and this is seen by its limited number of founders, high rate of endogamous marriages (82.04%), and low number of immigrants (3.97% before 1950). Beyond this, the population is generally attached to the traditional ways, retaining many old features of lifestyle, eating habits and behaviour. This genetic and environmental homogeneity facilitates the study of complex diseases. Participation study was voluntary: 917 women, ranging in age from 33 to 98 years old and previously informed that the study was conformed with international ethical guidelines, furnished a blood sample used for hematological and serological parameters, anthropometrical measurements, bioimpedance, Quantitative Ultrasonography (QUS) using a DBM Sonic Bone Profiler (IGEA Srl) and the structured interview to collected socio-economic, lifestyle, medical and pharmacological history and family history of osteoporosis. The main determinants of bone mass were modelled using General Linear Models. The T-score threshold for AD-SoS (Amplitude Dependent Speed of Sound) of -3.2 SD, was used to estimate the osteoporosis prevalence. The prevalence estimate was age adjusted using the general Italian population for 2005 (ISTAT). The 10 years probability of clinical vertebral fractures was calculated according to guidelines reported for diagnosis, prevention and therapy of osteoporosis (EDIMES - Pavia 2005). Using the genealogical data referred to the last 400 years and PedNavigator, a useful software able to reconstruct multigenerational pedigrres, we created 6 big families including all participants to the study; heritability estimate of QUS parameters was obtained by the variance component method implemented in the SOLAR software. The ultrasonic parameters AD-SoS and Ultrasound Bone Profile Index (UBPI) are strictly related to age and months since menopause. Multiple regression analysis detected significant association with height and alkaline phosphatase. UBPI resulted to be significantly correlated with weight, fat mass and menarche. Besides, AD-SoS and UBPI corrected for age and months since menopause, were found to be significantly associated with: hormone replacement therapy, sport activity (only AD-SoS), current or past diet (only AD-SoS), chronic use of steroids drugs, present or past chemotherapy, endocrine and gastrointestinal disorders. The prevalence of osteoporosis in baunei was 19.4 %. (95% CI: 17.0%-21.7%). The percentage of subjects with high 10 years risk of vertebrate fracture (>4%) was 4.1%. Using PedNavigator, we observed that individuals with reduced mineral bone density clustered in big families, showing that familiarity is an important risk factor for this disease. Heritability estimates of AD-SoS and UBPI, after adjusting for the associated covariates explaining more than 60% of the variability of trait variability, were found to be 30% and 64% respectively. (p
Databáze: OpenAIRE
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