Solid-phase approach to the synthesis of cyclen scaffolds from cyclotetrapeptides
| Autor: | Alcaro M. C., Orfei M., Chelli M., Ginanneschi M., Papini A. M. |
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| Rok vydání: | 2003 |
| Zdroj: | 44 (2003): 5217–5219. info:cnr-pdr/source/autori:Alcaro M. C., Orfei M., Chelli M., Ginanneschi M., Papini A. M./titolo:Solid-phase approach to the synthesis of cyclen scaffolds from cyclotetrapeptides/doi:/rivista:/anno:2003/pagina_da:5217/pagina_a:5219/intervallo_pagine:5217–5219/volume:44 |
| Popis: | Cyclen derivs., as coordinating ligands, have recovered considerable interest for the development of diagnostic and therapeutic drugs, mimicking the binding site of metalloproteins. We demonstrate that the on-resin redn. of head-to-tail cyclotetrapeptides, anchored to a solid support by the side-chain of a trifunctional amino acid, is an efficient synthetic strategy. The proposed approach leads to the cyclen scaffold still bound to the resin, ready for further decorations. |
| Databáze: | OpenAIRE |
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