Potential Utility of Cardio-Renal Biomarkers For Prediction and Prognostication of Worsening Renal Function in Acute Heart Failure: Cardio-Renal Biomarkers and WRF in AHF

Autor: Horiuchi Y, Wettersten N, van Veldhuisen D, Mueller C, Filippatos G, Nowak R, Hogan C, Kontos M, Cannon C, Mueller G, Birkhahn R, Taub P, Vilke G, Barnett O, McDonald K, Mahon N, Nunez J, Briguori C, Passino C, Maisel A, Murray P
Rok vydání: 2021
Zdroj: JOURNAL OF CARDIAC FAILURE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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ISSN: 1071-9164
Popis: BACKGROUND: Multiple different pathophysiologic processes can contribute to worsening renal function (WRF) in acute heart failure (AHF). METHODS AND RESULTS: We retrospectively analyzed 787 AHF patients for the relationship between changes in serum creatinine and biomarkers including brain natriuretic peptide (BNP), high sensitivity cardiac troponin I (hscTnI), galectin 3, serum neutrophil gelatinase-associated lipocalin (NGAL) and urine NGAL. WRF was defined as an increase of = 0.3 mg/dl or 50% in creatinine within first 5 days of hospitalization. WRF was observed in 25% of patients. Changes in biomarkers and creatinine were poorly correlated (r = 0.21) and no biomarker predicted WRF better than creatinine. In the multivariable Cox analysis, BNP and hscTnI, but not WRF, were significantly associated with the one-year composite of death or HF hospitalization. WRF with an increasing urine NGAL predicted an increased risk of HF hospitalization. CONCLUSIONS: Biomarkers were not able to predict WRF better than creatinine. One-year outcomes were associated with biomarkers of cardiac stress and injury but not with WRF, while a kidney injury biomarker may prognosticate WRF for HF hospitalization.
Databáze: OpenAIRE
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