Potential impacts of horizontal gene transfer on human health and physiology and how anthropogenic activity can effect it
| Autor: | Boto, Luis, Pineda, Manuel, Pineda, Rafael |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Universidad de Córdoba (España) |
| Rok vydání: | 2019 |
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| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Horizontal gene transfer (HGT) is widespread among prokaryotes driving their evolution. In this paper, we review the potential impact in humans of the HGT between prokaryotes living in close association with humans in two scenarios: horizontal transfer in human microbiomes and transfer between microbes living in human managed environments. Although our vision is focused on the possible impact of these transfers in the propagation of antibiotic resistance genes or pathogenicity determinants, we also discuss possible human physiological adaptations via gene transfer between resident and occasional bacteria in the human microbiome. The authors thank the two anonymous referees for their valuable comments. LB is supported by the grant CGL2016-75262-P of Spain DGI. RP is supported by a postdoctoral contract (Submodality 5.2.A) funded by the Research Plan of the University of Cordoba. |
| Databáze: | OpenAIRE |
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