Clinical characteristics of patients with atrial fibrillation treated with direct oral anticoagulants attended in primary care setting. The SILVER-AP study
| Autor: | de la Figuera, M, Cinza, S, Marin, N, Egocheaga, I, Prieto, MA |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Atencion Primaria r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0212-6567 |
| Popis: | Objective: To analyse the clinical characteristics and management of patients with non-valvular atrial fibrillation (NVAF) treated with direct oral anticoagulants (DOAC). Design: Observational, cross-sectional and multicentre study. Location: Autonomous Communities in which the general practitioner can prescribe DOAC (n = 9). Participants: The study included a total of 790 patients on chronic treatment with anticoagulants, and on whom therapy was changed, as well as being currently on treatment with DOAC for at least for 3 months. Main measures: A record was made of the sociodemographic and clinical management date. Results: Mean age was 78.6 +/- 8.4 years, and 50.5% of patients were men. Mean CHADS(2) score was 2.6 +/- 1.2, mean CHA(2)DS(2)-VASc score was 4.3 +/- 1.6, and the mean HAS-BLED score was 2.3 +/- 1.0. Mean duration of treatment with DOAC was 15.8 +/- 12.5 months. Rivaroxaban was the DOAC most frequently prescribed (57.8%), followed by dabigatran (23.7%), and apixaban (18.5%). Of the patients receiving rivaroxaban, 70.2% were taking the dose of 20 mg/daily. Of the patients receiving dabigatran, 41.7% were taking the dose of 150 mg twice daily, and in the case of apixaban, 56.2% were taking the dose of 5 mg twice daily. Satisfaction (ACTS Burdens scale 52.0 +/- 7.2 and ACTS Benefits scale 12.1 +/- 2.2), and therapeutic adherence (97.8% of patients took their medication regularly) with DOAC were high. Conclusions: Patients treated with DOAC in Spain have a high thromboembolic risk. A significant proportion of patients receive a lower dose of DOAC than that recommended according to their clinical profile. Satisfaction and medication adherence are high. (C) 2017 Elsevier Espana, S.L.U. |
| Databáze: | OpenAIRE |
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