Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
| Autor: | Omotoso, G.O., Kadir, R.E., Lewu, S.F., Gbadamosi, I.T., Akinlolu, A.A., Adunmo, G.O., Kolo, R.M., Lawal, M.O., Ameen, M.O. |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Research Journal of Health Sciences; Vol 6, No 1 (2018); 13-25 |
| ISSN: | 2360-7793 2467-8252 |
| Popis: | Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum.Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities.Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO.Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.Keywords: demyelination, cuprizone, cerebellar damage, Moringa oleifera, oxidative enzymes |
| Databáze: | OpenAIRE |
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