Haematological evaluation of Cryptolepis sanguinolenta stem ethanolic extract in rats
| Autor: | Ajayi, AF, Akhigbe, RE, Adewumi, OM, Olaleye, SB |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | International Journal of Medicine and Biomedical Research; Vol 1, No 1 (2012); 56-61 |
| ISSN: | 2277-0941 2315-5019 |
| Popis: | Background: The use of Cryptolepis sanguinolenta extract in medicare has gained attention since its discovery. Aim: This study sought to evaluate the haematological effect of ethanolic extract of Cryptolepis sanguinolenta stem in rat model. Materials and Methods: Control rats received 0.5ml of distilled water. Treated rats were administered oral doses of the extract at different concentrations (50, 150, and 250mg/kg body weight). All rats were maintained on a control diet. Treatment lasted for 21 days. Results: Red blood cells and haematological parameters were comparable in all groups. Similarly, total white blood cells, neutrophils and lymphocytes counts were not ignificantly altered except in rats treated with 250mg/kg/bw of the extract. However, administration of the extract led to a dose-dependent rise in platelet counts. Conclusion: This study showed that C. sanguinolenta stem ethanolic extract presents haematological challenges on white blood cells and platelets. It showed localized systemic toxicity by selectively stimulating the bone marrow. Keywords: Cryptolepis sanguinolenta, red blood cell, white blood cell, platelet, toxicity |
| Databáze: | OpenAIRE |
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