Involvement of cholinergic-muscarinic receptor in Anaphe venata-induced stretching-ataxia behavioral effects in rats
| Autor: | Bamitale, KDS, Akanmu, MA, Okonji, RE, Oboutor, EM, Ukponmwan, OE |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Zdroj: | International Journal of Biological and Chemical Sciences; Vol 5, No 3 (2011) |
| ISSN: | 1991-8631 1997-342X |
| Popis: | Anaphe venata entomophagy has previously been implicated in the aetiopathogenesis of seasonal ataxia in humans and altered motor function in rodents. Thus, we investigated the effect of A. venata PhosphateBuffer Saline (PBS) extract on stretching, ataxia and the possible mechanism(s) of action. Animals were divided into four groups (n = 6-12 per group) and graded doses of extract (100, 200 or 400 mg/kg) wereadministered intraperitoneally (i.p.) while the control group received saline. Behavioral scores were recorded for a period of 30 min immediately after the administration of saline or extract. The role of various receptors inthe extract induced stretching and ataxia was evaluated using known receptor antagonists in other groups of rats. The in-vitro cholinesterase inhibition assay of the extract was also performed. The protein profile of theextract was evaluated using the Sodium Dodecyl Sulphate (SDS)-Polyacrylamide gel electrophoresis. Results showed that the extract induced significant (p |
| Databáze: | OpenAIRE |
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